The best way t chek whether this can be combined with Layouts is trying 🙂 But as you state, they kind of overlap i functionality, right? I mean, this one is a page builder, and Layouts is a site builder which can also be used as a page builder. So it might not be neither easy nor usefull to have them both.
On the other hand, Layouts does not get integrated with other page builders. Instead, Layouts offers some integration plugins with popular themes, and some of them happen to pack a page builder. In that case, the Layouts integrations try to identify the modules (or cells, the name that you prefer) that this theme page builder offers and that Layouts lacks, and we integrate custom modules (or cells) for those pieces of functionality. I assume that with this plugin it might be similar, we have an API for that, but I must confess that integrating a plugin instead of a theme might not be even possible. By its own nature.
I will avoid making personal comments about simplicity or intuitiveness, this belongs to the subjective vision of each user 🙂